GnRHa to trigger final oocyte maturation: a time to reconsider
نویسندگان
چکیده
منابع مشابه
GnRHa to trigger final oocyte maturation: a time to reconsider.
Recently GnRH antagonist protocols for the prevention of a premature LH surge were introduced, allowing final oocyte maturation to be triggered with a single bolus of a GnRH agonist (GnRHa). GnRHa is as effective as hCG for the induction of ovulation, and apart from the LH surge a FSH surge is also induced. Until recently, prospective randomized studies reported a poor clinical outcome when GnR...
متن کاملPredicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger.
STUDY QUESTION Are there factors predicting the number of total and mature oocytes retrieved after controlled ovarian hyperstimulation (COH) utilizing a gonadotropin-releasing hormone (GnRH) antagonist protocol and a GnRH agonist (GnRHa) to induce oocyte maturation? SUMMARY ANSWER Peak estradiol (E₂) level, post-trigger LH and progesterone and the magnitude of LH rise are independent predicto...
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Human chorionic gonadotropin (hCG) has been used as a surrogate for the mid-cycle LH surge for several decades. Due to structural and biological similarities with LH, hCG binds to and activates the same receptor - the LH/hCG receptor. However, despite the fact that hCG effectively secures final oocyte maturation and ovulation, its use as a surrogate for LH has got several drawbacks - first and ...
متن کاملIndividual luteolysis pattern after GnRH-agonist trigger for final oocyte maturation
Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly common, as ovarian hyperstimulation syndrome is almost completely avoided. However, this approach might lead to reduced pregnancy rates due to severe luteolysis. This proof of concept study evaluated the extend of luteolysis by measuring progesterone levels 48 hours after oocyte retrieval in 51 pati...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2009
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dep246